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Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats

Dawood Hossaini, Kawsar Alami, Mohammad Latif Nazari, Khalil Ebrahimi, Mohammad Hossein Salehi, Sayed Yousof Mousavi.

Abstract
Aim: To investigate the effect of the aqueous extract of Afghan Ferula assa-foetida L. oleo gum resin on the withdrawal signs in morphine-dependent rats.
Methods: This study was carried out in 2018. Rats divided into 5 groups (1 Normal Saline, 1 Morphine, and 3 Extract groups). The rats that received morphine and extract became morphine-dependent by subcutaneous (s.c.) administration of morphine hydrochloride for 7 days (2.5, 2.5, 5, 10, 20, 40 mg/kg doses twice daily on 1st to 6th days respectively, and a single dose of 50 mg/kg on 7th day). The extract groups received 50, 75 and 100 mg/kg doses of the Ferula assa-foetida L. oleo gum resin aqueous extract by intraperitoneal (i.p.) administration simultaneously with morphine. Two hours after the administration of the last dose of morphine, Naloxone (3 mg/kg, i.p.) was injected and withdrawal signs were noted for 30 minutes.
Results: The results showed that the administration of the Ferula assa-foetida L. oleo gum resin aqueous extract (50, 75 and 100 mg/kg) significantly decreased most of the naloxone induced withdrawal signs in morphine-dependent rats (P<0.05).
Conclusion: Afghan Ferula assa-foetida L. oleo gum resin aqueous extract even in the lowest doses can alleviate the withdrawal signs in morphine-dependent rats.

Key words: Afghanistan; Ferula assa-foetida L.; Morphine dependence; oleo gum resin; Substance withdrawal signs


 
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How to Cite this Article
Pubmed Style

Hossaini D, Alami K, Nazari ML, Ebrahimi K, Salehi MH, Mousavi SY. Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. J Complement Med Res. 2021; 12(1): 70-74. doi:10.5455/jcmr.2021.12.01.07


Web Style

Hossaini D, Alami K, Nazari ML, Ebrahimi K, Salehi MH, Mousavi SY. Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. http://www.jocmr.com/?mno=100278 [Access: October 08, 2021]. doi:10.5455/jcmr.2021.12.01.07


AMA (American Medical Association) Style

Hossaini D, Alami K, Nazari ML, Ebrahimi K, Salehi MH, Mousavi SY. Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. J Complement Med Res. 2021; 12(1): 70-74. doi:10.5455/jcmr.2021.12.01.07



Vancouver/ICMJE Style

Hossaini D, Alami K, Nazari ML, Ebrahimi K, Salehi MH, Mousavi SY. Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. J Complement Med Res. (2021), [cited October 08, 2021]; 12(1): 70-74. doi:10.5455/jcmr.2021.12.01.07



Harvard Style

Hossaini, D., Alami, . K., Nazari, . M. L., Ebrahimi, . K., Salehi, . M. H. & Mousavi, . S. Y. (2021) Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. J Complement Med Res, 12 (1), 70-74. doi:10.5455/jcmr.2021.12.01.07



Turabian Style

Hossaini, Dawood, Kawsar Alami, Mohammad Latif Nazari, Khalil Ebrahimi, Mohammad Hossein Salehi, and Sayed Yousof Mousavi. 2021. Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. Journal of Complementary Medicine Research, 12 (1), 70-74. doi:10.5455/jcmr.2021.12.01.07



Chicago Style

Hossaini, Dawood, Kawsar Alami, Mohammad Latif Nazari, Khalil Ebrahimi, Mohammad Hossein Salehi, and Sayed Yousof Mousavi. "Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats." Journal of Complementary Medicine Research 12 (2021), 70-74. doi:10.5455/jcmr.2021.12.01.07



MLA (The Modern Language Association) Style

Hossaini, Dawood, Kawsar Alami, Mohammad Latif Nazari, Khalil Ebrahimi, Mohammad Hossein Salehi, and Sayed Yousof Mousavi. "Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats." Journal of Complementary Medicine Research 12.1 (2021), 70-74. Print. doi:10.5455/jcmr.2021.12.01.07



APA (American Psychological Association) Style

Hossaini, D., Alami, . K., Nazari, . M. L., Ebrahimi, . K., Salehi, . M. H. & Mousavi, . S. Y. (2021) Effect of Afghan Ferula assa-foetida L. oleo gum resin aqueous extract on withdrawal signs in morphine-dependent rats. Journal of Complementary Medicine Research, 12 (1), 70-74. doi:10.5455/jcmr.2021.12.01.07