E-ISSN 2577-5669
 

Original Research 


Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen.

Abstract
Objective: This study evaluated the anti-ulcer properties of Croton zambesicus leaves.
Materials and Methods: Group 1 was Control. 40mg/kg/bodyweight of Indomethacin (the ulcerogen) was administered to rats of Groups II – VII. Four hours after administrations of ulcerogen; rats of Groups III – VII were treated daily with oral administrations of 40mg/kg/bodyweight of Omeprazole, 5 and 10mg/kg/bodyweight of essential oils, 250 and 500mg/kg bodyweight of methanolic extract of Croton zambesicus leaves respectively for four days. Rats were euthanized on Day 1 (Group II) and Day 5 (Groups I and III – VII); thereafter, stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and alanine aminotransferase (ALT) status.
Results: Analyses of gastric acid assays and histo-pathological examinations showed dose-dependent statistically significant higher levels (P≤0.05) of gastric acidity and non-restorations of the gastric mucosa layer to pre-ulceration states in rats of Groups IV – VII treated with extract doses when compared to Group III. Statistically non-significant (Group IV) or significant (Groups V - VII) higher ALT levels (P≤0.05) were observed in liver samples of rats treated with doses of essential oils and methanolic extract of Croton zambesicus leaves when compared to Group II.
Conclusion: Our study observed low anti-ulcerogenic potentials of doses of essential oils and methanolic extracts of Croton zambesicus leaves.

Key words: Croton zambesicus, Indomethacin, Ulceration.


 
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How to Cite this Article
Pubmed Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. J Complement Med Res. 2014; 3(3): 97-102. doi:10.5455/jice.20140503090359


Web Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. http://www.jocmr.com/?mno=149785 [Access: November 15, 2018]. doi:10.5455/jice.20140503090359


AMA (American Medical Association) Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. J Complement Med Res. 2014; 3(3): 97-102. doi:10.5455/jice.20140503090359



Vancouver/ICMJE Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. J Complement Med Res. (2014), [cited November 15, 2018]; 3(3): 97-102. doi:10.5455/jice.20140503090359



Harvard Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen (2014) Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. J Complement Med Res, 3 (3), 97-102. doi:10.5455/jice.20140503090359



Turabian Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. 2014. Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. Journal of Complementary Medicine Research, 3 (3), 97-102. doi:10.5455/jice.20140503090359



Chicago Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. "Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.." Journal of Complementary Medicine Research 3 (2014), 97-102. doi:10.5455/jice.20140503090359



MLA (The Modern Language Association) Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen. "Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.." Journal of Complementary Medicine Research 3.3 (2014), 97-102. Print. doi:10.5455/jice.20140503090359



APA (American Psychological Association) Style

Adelaja Abdulazeez Akinlolu, Ghazali Olaide Kamaldeen, Deborah Francis, Mubarak Oloduowo Ameen (2014) Low Anti-ulcerogenic Potentials of Essential Oils and Methanolic Extract of Croton zambesicus Leaves.. Journal of Complementary Medicine Research, 3 (3), 97-102. doi:10.5455/jice.20140503090359





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