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Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe.

Cited by (2)

Abstract
Aim: The present research work was carried out to isolate and identify the chemical constituent responsible for the antinflammatory activity of Russelia equisetiformis.
Method: Isolation was carried out using column chromatography. The structure of the isolated compound was identified and established using the available spectroscopic techniques including high-resolution electron mass spectrum. The anti-inflammatory activity was evaluated using egg albumin-induced paw edema, formaldehyde–induced arthritis and cotton pellet granuloma in-vivo tests. Prednisolone was used as a standard drug.
Results: Lupeol was isolated as colorless crystals (mp 213-215OC).Lupeol at the doses of 10, 20, 40 mg/kg produced significant (P<0.05) and dose-dependent inhibition of egg albumin-induced edema and edematous response to arthritis. In chronic model of granuloma pouch in rat, lupeol (20 and 40 mg/kg), significantly (P<0.05) and also dose-dependently reduce the granuloma weight.
Conclusion: These findings suggest that lupeol isolated from extract of Russelia equisetiformis possesses anti-inflammatory activity in acute and certain aspects of chronic inflammation.

Key words: Russelia equisetiformis, Scrophulariacae, lupeol isolation, Anti-inflammatory activity


 
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How to Cite this Article
Pubmed Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. J Complement Med Res. 2012; 1(1): 25-29. doi:10.5455/jice.20120401054556


Web Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. http://www.jocmr.com/?mno=16330 [Access: November 15, 2018]. doi:10.5455/jice.20120401054556


AMA (American Medical Association) Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. J Complement Med Res. 2012; 1(1): 25-29. doi:10.5455/jice.20120401054556



Vancouver/ICMJE Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. J Complement Med Res. (2012), [cited November 15, 2018]; 1(1): 25-29. doi:10.5455/jice.20120401054556



Harvard Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe (2012) Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. J Complement Med Res, 1 (1), 25-29. doi:10.5455/jice.20120401054556



Turabian Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. 2012. Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. Journal of Complementary Medicine Research, 1 (1), 25-29. doi:10.5455/jice.20120401054556



Chicago Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. "Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent." Journal of Complementary Medicine Research 1 (2012), 25-29. doi:10.5455/jice.20120401054556



MLA (The Modern Language Association) Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe. "Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent." Journal of Complementary Medicine Research 1.1 (2012), 25-29. Print. doi:10.5455/jice.20120401054556



APA (American Psychological Association) Style

Awe Emmanuel Olorunju, Adeloye Adewale, Makinde Janet Modupe (2012) Anti-inflammatory activity of Russelia equisetiformis Schlecht & Cham: identification of its active constituent. Journal of Complementary Medicine Research, 1 (1), 25-29. doi:10.5455/jice.20120401054556





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