E-ISSN 2577-5669
 

Original Research 


Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function

Kunle Alabi Quadri, Christian Eseigbe Imafidon , Rufus Ojo Akomolafe.

Abstract
Aim: This study investigated the effects of oral kolaviron administration on proteinuria in Wistar rats.
Methods: The study used twenty (20) Wistar rats that were divided into 4 groups of 5 rats each. Group 1 received 2 ml/kg of propylene glycol, orally, for 30 consecutive days before they were sacrificed. Groups 2, 3 and 4 received graded doses of kolaviron at 100 mg/kg, 200 mg/kg and 400 mg/kg (p.o.) respectively, for 30 consecutive days before they were also sacrificed.
Results: Graded doses of kolaviron (100, 200 and 400 mg/kg p.o.) significantly lowered urine total protein and urine total protein–creatinine ratio with > 80 % reduction when compared with the control. However, creatinine clearance was significantly increased while the fractional excretions of Na+ and urea were significantly lowered. While plasma electrolytes were normal, the urinary excretion of Na+, K+ and Cl- where significantly increased in the kolaviron-treated groups. Urine output of the kolaviron-treated rats was significantly higher than that of the control without increase in both plasma and urine glucose level. Renal function biomarkers (creatinine and urea) of the rats indicated a kolaviron-enhanced improvement of renal function with an associated increase in their urine excretion. Micrographic evidence showed no apparent distortion of the kidney histoarchitecture following kolaviron administration to the rats.
Conclusion: It was concluded that kolaviron mitigated proteinuria and potentiated loop diuresis in Wistar rats, a pharmacological benefit that can be utilized for the adjuvant management or treatment of proteinuria-associated nephropathies.

Key words: Kolaviron; loop diuresis; proteinuria; Wistar rats


 
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How to Cite this Article
Pubmed Style

Quadri KA, CEI, Akomolafe RO, . Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. J Complement Med Res. 2019; 10(1): 58-67. doi:10.5455/jcmr.20190112122816


Web Style

Quadri KA, CEI, Akomolafe RO, . Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. http://www.jocmr.com/?mno=25807 [Access: February 15, 2020]. doi:10.5455/jcmr.20190112122816


AMA (American Medical Association) Style

Quadri KA, CEI, Akomolafe RO, . Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. J Complement Med Res. 2019; 10(1): 58-67. doi:10.5455/jcmr.20190112122816



Vancouver/ICMJE Style

Quadri KA, CEI, Akomolafe RO, . Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. J Complement Med Res. (2019), [cited February 15, 2020]; 10(1): 58-67. doi:10.5455/jcmr.20190112122816



Harvard Style

Quadri, K. A., , C. E. I. ., Akomolafe, R. O. & (2019) Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. J Complement Med Res, 10 (1), 58-67. doi:10.5455/jcmr.20190112122816



Turabian Style

Quadri, Kunle Alabi, Christian Eseigbe Imafidon, Rufus Ojo Akomolafe, and . 2019. Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. Journal of Complementary Medicine Research, 10 (1), 58-67. doi:10.5455/jcmr.20190112122816



Chicago Style

Quadri, Kunle Alabi, Christian Eseigbe Imafidon, Rufus Ojo Akomolafe, and . "Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function." Journal of Complementary Medicine Research 10 (2019), 58-67. doi:10.5455/jcmr.20190112122816



MLA (The Modern Language Association) Style

Quadri, Kunle Alabi, Christian Eseigbe Imafidon, Rufus Ojo Akomolafe, and . "Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function." Journal of Complementary Medicine Research 10.1 (2019), 58-67. Print. doi:10.5455/jcmr.20190112122816



APA (American Psychological Association) Style

Quadri, K. A., , C. E. I. ., Akomolafe, R. O. & (2019) Kolaviron mitigates proteinuria and potentiates loop diuresis in Wistar rats: Relevance to normal renal function. Journal of Complementary Medicine Research, 10 (1), 58-67. doi:10.5455/jcmr.20190112122816