E-ISSN 2577-5669
 

Letter to the Editor 


Drugs and dietary supplements with unproven effects in research and practice: Part 2

Sergei V. Jargin.

Abstract
Several examples are discussed in this review, where substances without proven effects were proposed for the practical use. The following is discussed here: generalizations of the hormesis concept and its use in support of homeopathy; phytoestrogens and soy products possibly having feminizing effects; glycosaminoglicans for the treatment of osteoarthritis and possibilities of their replacement by diet modifications; flavonoids recommended for the treatment of chronic venous insufficiency and varicose veins; acetylcysteine as a mucolytic agent and its questionable efficiency especially by an oral intake; stem cells and cell therapies. In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise it is named pseudo-placebo. Therapeutic methods with unproven effects should be tested in high quality research shielded from the funding bias. Patients participating in such research must be treated free of charge. As for animal experiments, they should be performed by integer researchers not influenced by conflicts of interest. The potential outcomes of some of these issues are not entirely clear, and the arguments provided here can initiate a constructive discussion.

Key words: acetylcysteine; hormesis; nutrition; osteoarthritis; phytoestrogens; soybean


 
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Pubmed Style

Sergei V. Jargin. Drugs and dietary supplements with unproven effects in research and practice: Part 2. J Complement Med Res. 2019; 10(3): 112-128. doi:10.5455/jcmr.20190314031843


Web Style

Sergei V. Jargin. Drugs and dietary supplements with unproven effects in research and practice: Part 2. http://www.jocmr.com/?mno=37129 [Access: October 22, 2019]. doi:10.5455/jcmr.20190314031843


AMA (American Medical Association) Style

Sergei V. Jargin. Drugs and dietary supplements with unproven effects in research and practice: Part 2. J Complement Med Res. 2019; 10(3): 112-128. doi:10.5455/jcmr.20190314031843



Vancouver/ICMJE Style

Sergei V. Jargin. Drugs and dietary supplements with unproven effects in research and practice: Part 2. J Complement Med Res. (2019), [cited October 22, 2019]; 10(3): 112-128. doi:10.5455/jcmr.20190314031843



Harvard Style

Sergei V. Jargin (2019) Drugs and dietary supplements with unproven effects in research and practice: Part 2. J Complement Med Res, 10 (3), 112-128. doi:10.5455/jcmr.20190314031843



Turabian Style

Sergei V. Jargin. 2019. Drugs and dietary supplements with unproven effects in research and practice: Part 2. Journal of Complementary Medicine Research, 10 (3), 112-128. doi:10.5455/jcmr.20190314031843



Chicago Style

Sergei V. Jargin. "Drugs and dietary supplements with unproven effects in research and practice: Part 2." Journal of Complementary Medicine Research 10 (2019), 112-128. doi:10.5455/jcmr.20190314031843



MLA (The Modern Language Association) Style

Sergei V. Jargin. "Drugs and dietary supplements with unproven effects in research and practice: Part 2." Journal of Complementary Medicine Research 10.3 (2019), 112-128. Print. doi:10.5455/jcmr.20190314031843



APA (American Psychological Association) Style

Sergei V. Jargin (2019) Drugs and dietary supplements with unproven effects in research and practice: Part 2. Journal of Complementary Medicine Research, 10 (3), 112-128. doi:10.5455/jcmr.20190314031843





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