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Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo.

Abstract
Objective. The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Tetrapleura tetraptera in stem-bark. Method: The healing activity was studied in 40 male rats using excision and incision wounds on normal and dexamethasone-suppressed wound healing. For each model, rats were divided in 4 groups as follows: control, dexamethasone, T. tetraptera and dexamethasone combined with T. tetraptera. Results: Data recorded exhibited a significant effect by the extract in the epithelialization time within 14 and 18 days of the normal and dexamethasone-induced healing delay rats respectively (p<0.05). The extract also significantly increased the wound tensile strength in dexamethasone treated rats. Histological examination of incision wounds of extract-treated group showed many fibroblasts and the same rats presented significant cutaneous tensile strength, suggesting important collagen crosslinkage. Conclusion: This study illustrated an excellent potential of the bark of T. tetraptera therapy on dermal wound healing with a possible mechanism of action related to epithelialization, contraction and tensile strength improvement.

Key words: Tetrapleura tetraptera, skin, excision wound, incision wound, epithelialization, tensile strength


 
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How to Cite this Article
Pubmed Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. J Complement Med Res. 2014; 3(2): 63-67. doi:10.5455/jice.20140129034637


Web Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. http://www.jocmr.com/?mno=48546 [Access: November 15, 2018]. doi:10.5455/jice.20140129034637


AMA (American Medical Association) Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. J Complement Med Res. 2014; 3(2): 63-67. doi:10.5455/jice.20140129034637



Vancouver/ICMJE Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. J Complement Med Res. (2014), [cited November 15, 2018]; 3(2): 63-67. doi:10.5455/jice.20140129034637



Harvard Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo (2014) Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. J Complement Med Res, 3 (2), 63-67. doi:10.5455/jice.20140129034637



Turabian Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. 2014. Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. Journal of Complementary Medicine Research, 3 (2), 63-67. doi:10.5455/jice.20140129034637



Chicago Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. "Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats." Journal of Complementary Medicine Research 3 (2014), 63-67. doi:10.5455/jice.20140129034637



MLA (The Modern Language Association) Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo. "Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats." Journal of Complementary Medicine Research 3.2 (2014), 63-67. Print. doi:10.5455/jice.20140129034637



APA (American Psychological Association) Style

David Emery Tsala, Solomon Habtemariam, Foyet Harquin Simplice, Martin Thierry Bella Ndzana, Abraham Abraham Jital, Theophile Dimo (2014) Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats. Journal of Complementary Medicine Research, 3 (2), 63-67. doi:10.5455/jice.20140129034637





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