E-ISSN 2577-5669
 

Original Research 


Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances

Abdulrazaq Bidemi Nafiu, Suliat Alimi, Abdussalam Babalola, Ayodele Temitope Ogunlade, Fatima Dobarako Muhammad, ABDUR RAHEEM ADESOLA IDOWU ABIOYE, Abdul musawwir Alli oluwafuyi, Lukman Aboyeji Oyewole, Olugbenga Akinola, Joseph Olajide Olayemi, Abdulbasit Amin, Wahab Imam Abdulmajeed, Ibrahim Musa, Mohammad Tariqur Rahman.

Abstract
Aim: Nigella sativa oil has been shown to improve metabolic syndrome-associated dyslipidemia and oxidative stress. Effects of N. sativa oil on letrozole-induced polycystic ovary syndrome (PCOS)-associated hormonal, metabolic, redox, and lipid dysregulation in rats were investigated.
Methods: Female Sprague-Dawley rats were randomly assigned into four groups (n=10 per group): control, PCOS, and PCOS treated with N. sativa oil (5 mL/kg/day or 10 mL/kg/day) once daily p.o. starting at day 7 after the commencement of letrozole (1mg/kg) until day 56. Body weight and estrous cycle were recorded starting from days 7 and 28 respectively until day 56. Rats were dissected and serum and ovaries were collected for biochemical and histomorphological assessments.
Results: N. sativa oil (10 mL/kg/day) treatment significantly increased: number of rats undergoing regular cycle (80% vs 20%; p< 0.05), average number of regular cycles (5.000.59 vs 0.200.42; p< 0.05), appearance of corpus luteum; but reduced number of cystic follicles (7.601.51 vs 6.100.19; p< 0.05) in PCOS rats. Body weight was also reduced by the oil in PCOS rats. However, ovarian weight, granulose and theca cells layers showed no significant change. The oil also restored altered circulating levels of gonadotropins, steroids and reduced fasting blood glucose. The ovarian total cholesterol, triglycerides, low density lipoprotein-cholesterol, malondialdehyde were markedly reduced while insulin sensitivity and ovarian high density lipoprotein-cholesterol, superoxide dismutase and glutathione peroxidase activities were greatly increased.
Conclusion: N. sativa oil improved polycystic ovarian-morphology and metabolic disorders via its anti-androgenic and insulin-sensitizing actions to ameliorate PCOS-associated dyslipidemia and redox disturbances.

Key words: Dyslipidemia; Letrozole; Nigella sativa oil; PCOS; Redox. Redox.


 
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How to Cite this Article
Pubmed Style

Nafiu AB, SA, AB, Ogunlade AT, Muhammad FD, ABIOYE ARAI, AmAo, Oyewole LA, Akinola O, Olayemi JO, Amin A, WIA, Musa I, Rahman MT, . Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. J Complement Med Res. 2019; 10(4): 186-199. doi:10.5455/jcmr.20190613045154


Web Style

Nafiu AB, SA, AB, Ogunlade AT, Muhammad FD, ABIOYE ARAI, AmAo, Oyewole LA, Akinola O, Olayemi JO, Amin A, WIA, Musa I, Rahman MT, . Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. http://www.jocmr.com/?mno=52554 [Access: February 15, 2020]. doi:10.5455/jcmr.20190613045154


AMA (American Medical Association) Style

Nafiu AB, SA, AB, Ogunlade AT, Muhammad FD, ABIOYE ARAI, AmAo, Oyewole LA, Akinola O, Olayemi JO, Amin A, WIA, Musa I, Rahman MT, . Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. J Complement Med Res. 2019; 10(4): 186-199. doi:10.5455/jcmr.20190613045154



Vancouver/ICMJE Style

Nafiu AB, SA, AB, Ogunlade AT, Muhammad FD, ABIOYE ARAI, AmAo, Oyewole LA, Akinola O, Olayemi JO, Amin A, WIA, Musa I, Rahman MT, . Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. J Complement Med Res. (2019), [cited February 15, 2020]; 10(4): 186-199. doi:10.5455/jcmr.20190613045154



Harvard Style

Nafiu, A. B., , S. A., , A. B., Ogunlade, A. T., Muhammad, F. D., ABIOYE, . A. R. A. I., , A. m. A. o., Oyewole, L. A., Akinola, O., Olayemi, J. O., Amin, A., , W. I. A., Musa, I., Rahman, M. T. & (2019) Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. J Complement Med Res, 10 (4), 186-199. doi:10.5455/jcmr.20190613045154



Turabian Style

Nafiu, Abdulrazaq Bidemi, Suliat Alimi, Abdussalam Babalola, Ayodele Temitope Ogunlade, Fatima Dobarako Muhammad, ABDUR RAHEEM ADESOLA IDOWU ABIOYE, Abdul musawwir Alli oluwafuyi, Lukman Aboyeji Oyewole, Olugbenga Akinola, Joseph Olajide Olayemi, Abdulbasit Amin, Wahab Imam Abdulmajeed, Ibrahim Musa, Mohammad Tariqur Rahman, and . 2019. Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. Journal of Complementary Medicine Research, 10 (4), 186-199. doi:10.5455/jcmr.20190613045154



Chicago Style

Nafiu, Abdulrazaq Bidemi, Suliat Alimi, Abdussalam Babalola, Ayodele Temitope Ogunlade, Fatima Dobarako Muhammad, ABDUR RAHEEM ADESOLA IDOWU ABIOYE, Abdul musawwir Alli oluwafuyi, Lukman Aboyeji Oyewole, Olugbenga Akinola, Joseph Olajide Olayemi, Abdulbasit Amin, Wahab Imam Abdulmajeed, Ibrahim Musa, Mohammad Tariqur Rahman, and . "Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances." Journal of Complementary Medicine Research 10 (2019), 186-199. doi:10.5455/jcmr.20190613045154



MLA (The Modern Language Association) Style

Nafiu, Abdulrazaq Bidemi, Suliat Alimi, Abdussalam Babalola, Ayodele Temitope Ogunlade, Fatima Dobarako Muhammad, ABDUR RAHEEM ADESOLA IDOWU ABIOYE, Abdul musawwir Alli oluwafuyi, Lukman Aboyeji Oyewole, Olugbenga Akinola, Joseph Olajide Olayemi, Abdulbasit Amin, Wahab Imam Abdulmajeed, Ibrahim Musa, Mohammad Tariqur Rahman, and . "Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances." Journal of Complementary Medicine Research 10.4 (2019), 186-199. Print. doi:10.5455/jcmr.20190613045154



APA (American Psychological Association) Style

Nafiu, A. B., , S. A., , A. B., Ogunlade, A. T., Muhammad, F. D., ABIOYE, . A. R. A. I., , A. m. A. o., Oyewole, L. A., Akinola, O., Olayemi, J. O., Amin, A., , W. I. A., Musa, I., Rahman, M. T. & (2019) Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. Journal of Complementary Medicine Research, 10 (4), 186-199. doi:10.5455/jcmr.20190613045154