E-ISSN 2577-5669
 

Original Research 


Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart

Jacqueline Ze Minkande , Sidiki Aboubakar, David Emery Tsala , Solomon Habtemariam, Nga Nnanga.

Abstract
Aim. The effects of the water extract of the leaves of Euphorbia Poissonii (Euphorbiacea) on frog heart contraction and its possible mechanism action were investigated. Method. By using the Langerdhorff model of the isolated frog heart preparation, the strength and frequency of heart contractions as well as cardiac output were measured under perfusion with test drugs. Results and conclusion. When assessed with digoxin and adrenaline as positive controls, the water extract (3 mg/mL) exhibited significant positive inotropic (70.00% improvement compared to baseline) and chronotropic (17.79% improvement) effects. Additionally, heart contractility was inhibited in the presence of propranolol and amlodipine, suggesting that the testing extract is having adrenergic properties. Reversible heart arrest was noticed at the dose of 6 mg/mL.

Key words: adrenergic agonism; Euphorbia poissonii; frog heart; inotropic and chronotropic effects


 
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How to Cite this Article
Pubmed Style

JZM, SA, DET, SH, Nnanga N, . Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. J Complement Med Res. 2021; 12(1): 107-112. doi:10.5455/jcmr.2021.12.01.13


Web Style

JZM, SA, DET, SH, Nnanga N, . Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. http://www.jocmr.com/?mno=69068 [Access: October 08, 2021]. doi:10.5455/jcmr.2021.12.01.13


AMA (American Medical Association) Style

JZM, SA, DET, SH, Nnanga N, . Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. J Complement Med Res. 2021; 12(1): 107-112. doi:10.5455/jcmr.2021.12.01.13



Vancouver/ICMJE Style

JZM, SA, DET, SH, Nnanga N, . Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. J Complement Med Res. (2021), [cited October 08, 2021]; 12(1): 107-112. doi:10.5455/jcmr.2021.12.01.13



Harvard Style

, J. Z. M. ., , S. A., , D. E. T. ., , S. H., Nnanga, N. & (2021) Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. J Complement Med Res, 12 (1), 107-112. doi:10.5455/jcmr.2021.12.01.13



Turabian Style

, Jacqueline Ze Minkande , Sidiki Aboubakar, David Emery Tsala, Solomon Habtemariam, Nga Nnanga, and . 2021. Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. Journal of Complementary Medicine Research, 12 (1), 107-112. doi:10.5455/jcmr.2021.12.01.13



Chicago Style

, Jacqueline Ze Minkande , Sidiki Aboubakar, David Emery Tsala, Solomon Habtemariam, Nga Nnanga, and . "Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart." Journal of Complementary Medicine Research 12 (2021), 107-112. doi:10.5455/jcmr.2021.12.01.13



MLA (The Modern Language Association) Style

, Jacqueline Ze Minkande , Sidiki Aboubakar, David Emery Tsala, Solomon Habtemariam, Nga Nnanga, and . "Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart." Journal of Complementary Medicine Research 12.1 (2021), 107-112. Print. doi:10.5455/jcmr.2021.12.01.13



APA (American Psychological Association) Style

, J. Z. M. ., , S. A., , D. E. T. ., , S. H., Nnanga, N. & (2021) Cardiotonic activity of the aqueous extract of euphorbia poissonii on the isolated frog heart. Journal of Complementary Medicine Research, 12 (1), 107-112. doi:10.5455/jcmr.2021.12.01.13