Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study

Hariprasath Nagarajan; D. Sri Sakthi; Meignana Arumugham Indiran; Rajesh shanmugam

doi:10.5455/jcmr.2023.14.02.05

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J Complement Med Res. 2023; 14(2): 35-40

doi: 10.5455/jcmr.2023.14.02.05

Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam.

Abstract
Introduction: Nigella sativa, also known as black seed, black cumin, and/or Habbatul Barakah, is a medicinal herbal plant.
Thymoquinone (TQ), one of Nigella sativa's active ingredients, has been shown to be anticarcinogenic, anti-inflammatory,
analgesic, and antimicrobial. Hydroxyapatite (HA) is an inorganic mineral with the apatite lattice structure (A10(BO4)6C2).
The aim of the current study is to incorporate thymoquinone with blackcumin hydroxyapatite crystals to form a new
nanoformulation and to find out its cytotoxicity and antimicrobial properties against dental pathogens.
Materials and method: Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Candida albicans were
the species used. The antimicrobial efficacy of the nanoparticles was evaluated using the agar well diffusion method at
different concentrations ranging from 25 micron litres to 100 micron litres. UV double beam spectrophotometers in the
wavelength range of 250-750nm were used to characterise the synthesised nanoparticles.
Results: The zone of inhibition against Staphylococcus mutans and Candida albicans was found to be highest at 100 L
concentration. As the concentrations of new nano formulation solution increased, the mean zone of inhibition grew.
Conclusion: The study showed that there is potential antimicrobial property of the new nano formulation against
Streptococcus mutans and Staphylococcus aureus also there is antifungal activity against Candida albicans

Key words: black cumin, hydroxyapatite crystals, thymoquinone, Nano formulation

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Pubmed Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam. Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . J Complement Med Res. 2023; 14(2): 35-40. doi:10.5455/jcmr.2023.14.02.05

Web Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam. Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . https://www.jocmr.com/?mno=143910 [Access: May 26, 2023]. doi:10.5455/jcmr.2023.14.02.05

AMA (American Medical Association) Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam. Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . J Complement Med Res. 2023; 14(2): 35-40. doi:10.5455/jcmr.2023.14.02.05

Vancouver/ICMJE Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam. Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . J Complement Med Res. (2023), [cited May 26, 2023]; 14(2): 35-40. doi:10.5455/jcmr.2023.14.02.05

Harvard Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam (2023) Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . J Complement Med Res, 14 (2), 35-40. doi:10.5455/jcmr.2023.14.02.05

Turabian Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam. 2023. Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . Journal of Complementary Medicine Research, 14 (2), 35-40. doi:10.5455/jcmr.2023.14.02.05

Chicago Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam. "Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study ." Journal of Complementary Medicine Research 14 (2023), 35-40. doi:10.5455/jcmr.2023.14.02.05

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Hariprasath Nagarajan,D. Sri Sakthi, Meignana Arumugham Indiran, Rajesh shanmugam (2023) Evaluation of antimicrobial property of thymoquinone synthesized with black cumin hydroxyapatite crystals against dental pathogens - An Invitro study . Journal of Complementary Medicine Research, 14 (2), 35-40. doi:10.5455/jcmr.2023.14.02.05

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