The word ’ADOLESCENT’’ is derived from the Latin word “ADOLESCERE’’ which means to grow to maturity that indicated the detaining features of adolescence. Adolescents belong to vital age group because they are the important people to parenthood but also they are threshold between childhood andadulthood .As they are attempt to cross this threshold, they face various psychological and developmental changes. Menstruation is the first indication of puberty. Majority of the girls 88% preferred sanitary pads rather than clothes as menstrual absorbent in our study. Privacy for washing, changing, or cleaning purpose is very important for proper menstrual care, and lack of knowledge was an important problem found in our study. Different restrictions were practiced by most of the girls in the present study, possibly due to their ignorance and false perceptions regarding menstruation. Every girl child should be aware about menstruation, which is an important event at the threshold of adolescence, and ideally a mother should be the main informant at this tender age and mother was the first informant in case of 91.5% of girls.Post-test results showed significant improvement in the level of knowledge about menstrual care and prevention of RTI. thus , it can be concluded that self-instructional module is an effective method of teaching staff nurses to increase level of know ledge about practices of menstrual care.