Tattooing and body piercing have gained widespread popularity across various demographics, becoming significant elements of contemporary culture. However, these body modification practices are not without health risks. A Study to evaluate the Effectiveness of Information Booklet on Knowledge regarding Health Risk related to Body Piercing and Tattooing among Adolescents at selected inter colleges, Kanpur Uttar Pradesh. The research study was conducted in Rama University. 60 samples were selected by using Non-probability convenience sampling technique and the data was collected by using self-structured knowledge questionnaire. The data was collected and analysed based on descriptive and inferential statistics. The result of the study showed that post-test mean score (19.3) was high when compared to the pre-test mean score was (12.5). The obtained “t” value 13.10 was greater than value of df 59 which was p<0.05 level of significant differences between pre-test and post-test level of knowledge hence the formulated research Hypothesis H1 was accepted. The test revealed that there were significant with association with Age, Gender, Religion, Class, Previous knowledge,at p<0.05 level of significance.The study concluded that Information Booklet was effective and improve knowledge regarding Health risk related to tattooing and body piercing among adolescents of inter college.