This study evaluated the effectiveness of an educational program for the prevention and management of multisystem inflammatory syndrome (MIS-C) in children. This study aims to evaluate the effectiveness of school teachers' knowledge on the prevention and management of MIS-C. MIS C is a serious disease associated with COVID-19. Symptoms of many diseases. This study included a group pre-test and post-test designed for each experiment to assess the knowledge of primary school teachers before and after the educational intervention. The target uses the criteria used to select the model. This educational model has primary school teachers in Kanpur. Data was collected using a self-administered questionnaire. The following is a general introduction to the presentation of the disease, etiology and risk factors. Apply clinical, problem, prevention and management strategies to MIS-C. Results showed that knowledge scores increased significantly after the intervention (P<0.005), indicating that the training program effectively better participants' understanding of prevention and management of MIS-C. This study concluded that the training plan was important in providing primary school teachers with the necessary knowledge to prevent and manage MIS-C, as well as its ability to improve the utility of outcomes and reduce the burden of the disease.