Background: Maternal mortality remains critically high worldwide, particularly in Africa. Maternal recognition of obstetrical danger signs is critical for timely access to emergency care and to reduce maternal mortality. Aim: To assess women’s knowledge and attitude regarding dangerous signs during pregnancy. Design: descriptive research design. Setting: The research was conducted in antenatal care clinic at Mainsheet El bakery hospital, Cairo governorate, Egypt. Subjects : (138) pregnant women who visit an antenatal care clinic at Mainsheet El bakery hospital. Tools : Tool I: A structured interviewing: questionnaire with two parts (demographic information, obstetrical history, and antenatal care history) .Tool II: A structured assessment of women's knowledge of pregnancy danger signs. Tool III : A structured assessment of women’s attitudes regarding danger signs during pregnancy. Results: Most pregnant women had an unsatisfactory level of knowledge and a negative attitude regarding danger signs during pregnancy. Conclusion: There was highly statistically significant relationship between pregnant women’s knowledge level and their attitude toward the signs of pregnancy. Recommendations : Developed educational program for pregnant women about danger signs during pregnancy to disseminate correct knowledge and a positive attitude about danger signs during pregnancy .