Risedronate sodium, a bisphosphonate, is commonly used for the treatment of osteoporosis and other bone-related disorders. However, its poor oral bioavailability and short half-life limit its therapeutic efficacy. Nanosponges, as a novel drug delivery system, offer the potential to enhance the solubility, stability, and controlled release of drugs. This study focuses on the development and characterization of risedronate sodium-loaded nanosponges to improve its therapeutic efficacy.