Osteoarthritis knee is the most common form of arthritis and a major cause of pain and disability in the elderly population. 80 % of the people have radiographic evidence of osteoarthritis, but only 25-30% are symptomatic. In India 22% to 30% of the population suffers from Osteoarthritis knee, the second most common rheumatologic problem. Osteoarthritis Knee was estimated to be the 10th leading cause of non-fatal burden. More common in women than in men, nearly 45% of women over the age of 65 years have symptoms of osteoarthritis. A 62-year-old female has been suffering by drawing pain in both knee joints for the last 6 years, they complain worse by walking, ascending stairs, cold exposure, pressure, and working in water; feels better during sitting (rest). From the totality of the patient, Calcarea carbonica 30C was prescribed. Then gradually had improved knee pain and quality of life.