The study focuses on the formulation and optimization of a ternary complex of griseofulvin using β-cyclodextrin (β-CD) and PVP K30 to enhance the drug’s solubility and bioavailability. Griseofulvin, an antifungal agent, has limited water solubility, which hinders its absorption and therapeutic effectiveness. The inclusion of β-CD, a cyclic oligosaccharide, and PVP K30, a hydrophilic polymer, aims to improve its solubility by forming a ternary inclusion complex.