Many campaigns rolled out to enhance the awareness of people on COVID-19 prevention, control, and promotive measures. Siddha polyherbal formulations, namely Kabasura kudineer (KSK) and Nilavembu kudineer (NVK) were recommended by the Ministry of AYUSH, Govt of India as an advisory for AYUSH interventions for COVID-19. This study was conducted to estimate traditional siddha medicine practices and preventive measures against COVID 19 among the population accessing research clinic facility and the residents of containment zones of Chennai, the capital of Tamil Nadu State, India. We interviewed 569 participants, and most of the participants aware of adopting general preventive measures of COVID-19, 85% practiced hand wash and 95% wore mask. Siddhaspecific measures such as drinking of KSK is reported in 77% (n=444, 77%) and NVK in 60% (n=360) in the containment zone areas for prevention and control of COVID19. The population behavior documents belief in traditional medical system and to consider integrated medical approach for effective communication during public health emergencies