Background & aim of study: This study investigated the incidence of postoperative nausea and vomiting (PONV) in patients with a body mass index (BMI) greater than 35 who underwent sleeve surgery and were maintained with Propofol anesthesia. Postoperative nausea and vomiting (PONV) is a common complication following sleeve surgery, and Propofol is a commonly used anesthetic. Material & method: In a prospective descriptive study, we used a non-randomized allocation strategy to allocate 55 patients who met the inclusion criteria. The patients were monitored for standard hemodynamic monitoring for blood pressure and heart rate was recorded prior to induction. The occurrence and severity of nausea and vomiting were recorded using a standardized scoring system. The inclusion criteria were American Society of Anesthesiologists (ASA) I, II, or III classification, BMI greater than 35, age between 18-45 years, and undergoing elective sleeve surgery. The exclusion criteria were ASA IV or V classification, BMI less than 35, and Patients with a known allergy to propofol. The researchers calculated the necessary sample size to be n = 58. Participants were selected using a convenience sampling method. The study ensured that the sample met the inclusion and exclusion criteria and that the sampling method was practical and feasible. Results: The variables examined include age, gender, BMI, surgery duration, antiemetic medication, smoking, history of nausea and vomiting, and premedication. The study finds that there is a statistically significant differences in the number of patients with a history of motion sickness and a history of PONV between the two groups. Patients who had a history of motion sickness or PONV were more likely to experience PONV after surgery. However, there is no statistically significant differences in age, sex, smoking status, surgery duration, anesthesia duration, or fluid balance between the two groups (with or without PONV). Conclusion: The study aimed to identify factors associated with the incidence of postoperative nausea and vomiting (PONV) through logistic regression analysis. The results indicated that there were no significant differences in age, sex, smoking status, surgery duration, anesthesia duration, or fluid balance between patients with and without postoperative nausea and vomiting (PONV). However, patients with a history of motion sickness or a history of PONV had significantly higher odds of experiencing PONV. The study suggests that preoperative assessment of patients for a history of motion sickness and PONV may be useful in identifying patients at higher risk for PONV and implementing preventative measures such as antiemetic medication. However, further research is needed to confirm these findings and explore additional factors that may contribute to the development of PONV.