Background: An infusion pump is a medical device that delivers fluids, such as nutrients and medications, into a patient’s body in controlled amounts. Nurses have an important role in ensuring safety in the infusion pumps’ medication administration process. Aim of the study was to assess nurses' performance regarding smart infusion pump in relation to medication administration among pediatric patients. Design: A descriptive exploratory design was utilized in carrying out this study. Settings: The study was carried at three places in Mansoura New General Hospital Dakahlia Governate NICU, PICU and inpatients ward. Study subjects: A purposive sample of 120 nurses working at previously mentioned settings (45) nurses from NICU, (56) nurses from PICU and (19) nurses from in-patients’ pediatric wards. Data collection tools: Tool I. Structured Questionnaire Sheet. Tool II. An Infusion Pumps' Medication Administration Observational Checklist. Results: Regarding nurses’ total knowledge, more than three quarters of studied nurses had unsatisfactory total knowledge regarding smart infusion pump whenever, about one quarter of them had a satisfactory total knowledge. In relation to total nurses’ practice, the study revealed that the majority of studied nurses had incompetent total practice regarding smart infusion pump whenever, the minority of them had a competent total practice. There was statistically significant relation between nurses’ total knowledge and their total practices related to SIP Conclusion: regarding nurses’ total knowledge, more than three quarters of studied nurses had unsatisfactory total knowledge regarding smart infusion pump. In addition, the majority of studied nurses had incompetent total practice regarding smart infusion pump. Recommendations: Provide in-service educational programs and upgrading courses based on pediatric nurses' needs and evidence-based guidelines to improve their knowledge and practice related to administration intravenous medications using infusion pump.