The primary objective of this study was to develop and evaluate Eudragit-coated pectin microspheres (EU-MS) for targeted delivery of curcumin (CUR) to the colon. To achieve this, different ratios of CUR and pectin (ranging from 1:3 to 1:6), stirring speeds (ranging from 500 to 2000 rpm), and concentrations of emulsifier (ranging from 0.75 to 1.5% w/v) were employed to produce pectin microspheres (P-MS). The preparation yield and encapsulation efficiency (EE) of all P-MS were found to be high. The optimal formulation was determined to be MS with a drug:polymer ratio of 1:4, a stirring speed of 1000 rpm, and an emulsifying agent concentration of 1.25% w/v. The pectin microspheres were coated with Eudragit using the oil-in-oil solvent evaporation method, with a coat:core ratio of 5:1. The surface morphology, particle size and distribution, swellability, EE, and in vitro drug release in simulated gastrointestinal fluids (SGF) were evaluated for both the P-MS and EU-MS. The release of CUR from the EU-MS was influenced by the pH of the medium. In an acidic environment, the release rate was significantly slower, whereas at pH 7.4, the drug was released rapidly. Based on the findings of this study, it can be concluded that EU-MS show promise as controlled release carriers for delivering CUR specifically to the colon region.