In Search New Anti-Inflammatory Agents, P38 Kinase A Proline Directed Serine Threonine Mitogen Activated Protein Kinase Has Been Known As Attractive Target For Anti-Inflammatory Drug Discovery. An Attempt Has Been Made Here To Search New Scaffold With Added Attributes As P38 Kinase Inhibitor Employing Ligand Based Pharmacophore Development And Virtual Screening. A Best Pharmacophore Was Developed Using Thirty Two Compounds With Know IC50 Values As Training Set By Hypogen With R2 0.89 And Root Mean. Square Deviation (RMSD) 1.282 Consisting Features Like Hydrogen Bond Acceptor And Ring Aromatics And Cost Difference Of 48.4. The Aforementioned Model Was Validated By Predicting Activity Of Training Set Consisting 150 Diverse Set Of Molecules Which Showed Predictive R2 0.6. With The High Confidence The Pharmacophore Was Explored For Screening A Database Of 0.3 Million Molecules Which Resulted In 560 New Hits And Among Them Fifty Two Compounds Have Been Identified As Best Active Structures.