The article investigates approaches to the treatment of nephrotic syndrome. Nephrotic syndrome (NS) is one of the main chronic kidney diseases, this disease is diagnosed in patients of any age. At the present stage, there is no universal treatment for this condition. NS therapy currently includes angiotensin converting enzyme inhibitors, angiotensin receptor blockers, monoclonal antibodies, steroids and immunosuppressants. Steroids continue to be the initial approach to the treatment of patients with NS and are considered the basis of therapy. In this regard, it is necessary to consider various innovative approaches to the treatment of this disease in order to increase the effectiveness of NS therapy.