The main objective of the present study is to examine the effectiveness of educational life skills on hope and happiness in academic students. The statistical population includes all students in Sabzevar University of Medical Sciences among of them 40 respondents were elected as samples. This quasi-experimental research was conducted with pretest and posttest on tested and control groups. Both groups completed hope questionnaire (Snyder et al. 1991) and Oxford Happiness Questionnaire (Argyle and Lu, 1990) as pretest and posttest. Data were analyzed using Multivariate Covariance Analysis (MANCOVA) and Univariate Covariance Analysis (UNCOVA) by the aid of SPSS-19. The results of this study showed that there was significance difference between groups of training of educational life skills and control in terms of variable of hope and happiness in students.