This study investigates the effects of different cooling and lubrication conditions on the cutting performance and surface integrity during end face milling of Inconel 718, a nickel-based superalloy known for its exceptional mechanical properties and resistance to high temperatures. Inconel 718 is widely used in aerospace, nuclear, and gas turbine applications, making the optimization of its machining processes critical for enhancing efficiency and product quality. The research evaluates various cooling and lubrication methods, including dry machining, flood cooling, and the use of cutting fluids, to determine their impact on key performance indicators such as tool wear, cutting forces, surface roughness, and microstructure of the machined surface. Experimental results reveal that optimal cooling and lubrication conditions significantly improve cutting performance by reducing tool wear and enhancing surface integrity, with flood cooling showing the most promising results in terms of minimizing thermal damage and achieving finer surface finishes. This study provides valuable insights into the machining of Inconel 718, contributing to the development of more effective machining strategies that can improve productivity and product quality in industries that utilize superalloys.