A six years old male patient with a history of polydipsia and polyuria and adiagnosis of central insipidus diabetes, and prescribed desmopressin has been examined by an Iranian traditional medicine (ITM) specialist for an alternative treatment plan. Based on the six essential rules in ITM and with the purpose of restoring and balance of the temperament and humors, patient has undergone nutritional, medicinal, and manual changes which have been effective in treating his condition. During the 4 months follow-up no recurrence has been observed which suggest the effectiveness of the treatment plan. Further studies should lighten the therapeutic potency of ITM on other metabolic and systemic diseases.