Background: Revascularization of critically ischemic foot is a complex task aimed at improving wound healing. This study focused on comparing the effectiveness of two strategies of angioplasty in terms of healing, patency, and limb salvage. Aim and Objectives: To compare the clinical outcomes of parallel and sequentialtibial angioplasty in patients with lower limb-threatening ischemia, To evaluate the safety and efficacy of both angioplasty techniques, and To determine the impact of both techniques on limb salvage and patient quality of life. Patients and Methods: AclinicaltrialwasconductedattheVascularSurgeryDepartmentofKaferelsheikh University Hospitals, involving 60 patients with Rutherford grade 5, and 6 CLI. Of these, 30 patients Sequential angioplasty, while 30 received parallel angioplasty. The primary endpoint was wound healing and relief of pain, and secondary endpoints included patency and limb salvage. Kaplan-Meier analysis was used to evaluate limb salvageandpatency. Results: This study compares “ Sequential" and" parallel" revascularization in patients, finding no significant demographic differences in age, gender, tobacco use, diabetes, hypertension, dyslipidemia, and ischemic heart disease. Demographic data showed no significant differences between the groups in terms of age, gender, and prevalence of comorbidities (p>0.05). Patient presentations and TASC classifications were also similar (p>0.05). At 12 months, outcomes including full epithelization/healing, re-occlusion/revision, 30-day mortality, major amputation, limb salvage, and primary patency rates did not differ significantly between the groups(p>0.05).Ankle-BrachialIndex(ABI)valuespre-andpost-interventionwere comparable(p>0.05).Thesefindingsindicatethatbothangioplastyapproachesare equally effective, with no significant differences in clinical outcomes, thereby supportingthe reliability ofeither method inclinical practice. Conclusion: Sequential tibial angioplasty showed no significant difference in wound healing, limb salvageandamputation-freesurvivalcomparedwithparallelangioplastyovershort to intermediate term