Background:WHO is recommending and enhancing the use of plant-derived medicines because they are easily available and affordable. Herbs contain different types of biological ingredients or secondary metabolites for their growth and development and these biological ingredients can be used by humans to treat various diseases and disorders. Main body of abstract: Macrotylomauniflorum, frequently called horse gram in English and kulthi in Hindi, is a commonly grown plant in Asia, Australia, and Africa. It is primarily found on the soil edges of arid places in the Western Ghats region. In traditional medical cultures, it was used to cure many ailments, including bronchitis, hemorrhoids, asthma, tumors, and inflammation. The plant's seeds are widely consumed as a green vegetable in many parts of India. Because shrub extracts contain a comprehensive range of phytoconstituents, comprising tannin, flavonoids, alkaloids, triterpenoid, saponin, carbohydrates, phenolics, amino acids, and mucilage, it is believed that the seeds are rich in proteins and have medicinal qualities.Nanotechnology has opened up new possibilities for enhancing M. uniflorum extract's potency, availability, and durability, all of which will benefit the treatment of medical conditions. To tackle more chronic diseases such as asthma, cancer, and diabetes, it is necessary to introduce nanoparticles like NDDS into the standard medical system. Short conclusion: The polyphenolic components of M. uniflorum function as a reducer in synthesizing nanocomposites, which are the intended phytoconstituents that led to the selection of this particular plant. A range of nanoformulations, such as zinc oxide, gold, and silver nanoparticles, have been created using M. uniflorum extract and exhibit tremendous therapeutic promise for treatingseveral illnesses.