Introduction: Physicians and other healthcare personnel have an important role during epidemic of public health crises such as COVID-19 pandemic . It has been observed that this pandemic has increased the stress of different communities, especially medical staff. Since the widespread of this disease, no research has been conducted on the effects of this pandemic on the stress and resilience of pediatric and emergency assistants of Iran. The present research aims to evaluate the association between resilience and stress of coronavirus (COVID-19) in pediatric and emergency assistants of Iran University of Medical Sciences in 2021. Method: The present research is a cross-sectional study. The statistical population included 52 pediatric and emergency assistants of Ali Asghar and Rasoul Akram hospitals in Tehran , 2021. The census sampling method was implemented for selecting the samples. For deliberating content validity and reliability, 30 questionnaires were initially examined and after confirmation , other samples were examined. In the present study, 2 questionnaires were used and 52 people responded to them, and then the two components of content validity ratio and content validity index (CVI and CVR) were evaluated. For determining the reliability , the Cronbach's alpha coefficient formula was implemented, after calculating Conor and Davidson resilience alpha, (CD-RIS) the score 0.90 and for the anxiety scale of coronavirus in pediatric and emergency assistants, digit 0.89 was obtained, and considering that both of them are greater than. 0.7 , appropriate reliability was obtained. Considering the normality of the data, Pearson correlation coefficient was used for analyzing the association between resilience and stress in pediatric and emergency assistants . Results: Since sig was higher than 0.05 (0.1), the null hypothesis was confirmed and the opposite hypothesis was rejected, and no significant association was found among these two variables (P = 0.6). The results also demonstrated that there was no association between resilience and stress in assistants and residents. Since there was no association among the two variables, the intensity and directions were not assessed. The findings showed that most pediatric assistants and residents were stressed about the new coronavirus disease and the health of individuals that are close to them. According to the chi-square test and probability value, it was found that there was no significant association among the demographic characteristics and stress of coronavirus in pediatric and emergency assistants and their resilience scale.