This comprehensive review explores the potential role of lignocaine in addressing postoperative airway symptoms associated with laparoscopic surgery. While offering numerous benefits, laparoscopic procedures often present challenges related to respiratory discomfort in the postoperative phase. Lignocaine, a versatile local anesthetic with antiarrhythmic properties, is investigated for its mechanisms of action, including sodium channel blockade and anti-inflammatory effects. The review examines various administration routes-intravenous, topical, and nebulized-and evaluates their effectiveness in mitigating postoperative airway symptoms. Key findings indicate that lignocaine may contribute to expedited recovery times and improved patient-reported outcomes related to comfort and satisfaction. Safety considerations, including potential side effects, are discussed alongside practical considerations for implementation in clinical practice. The implications for personalized approaches and the potential transformation of perioperative care underscore lignocaine's promising role in enhancing postoperative airway comfort in laparoscopic surgery. Further research and clinical experience are crucial to refining our understanding and optimizing lignocaine's integration into routine practices.