The rheumatic condition ankylosing spondylitis (AS) is a subgroup of the spondyloarthropathies (SpA), which have a strong correlation with the genetic variant HLA- B27. Ankylosing spondylitis (AS) is a spine and sacroiliac joint primarily affecting chronic systemic inflammatory illness. It takes years for AS to reach its clinically evident stage, which includes sacroiliitis, loss of spinal mobility, extra-articular symptoms, peripheral arthritis, and reduced quality of life as a result of structural degeneration. AS is a slowly developing condition. Early in the course of the illness, inflammation-related back pain and stiffness are noticeable; however, a persistent aggressive state can result in severe discomfort and pronounced axial immobility or deformity. A 21-year female patient was diagnosed with AS, and she was identified as having positive HLAB27 and positive Schober’s test. she received 15 days of treatment using a combination of Panchakarma procedures and certain Ayurvedic medications. Based on the Bath Ankylosing Spondylitis Disease Activity Index score, an evaluation criterion was created (BASDAI). A total of two evaluations-one before and one after treatment-were undertaken. The patient's BASDAI scores have improved significantly. It has been demonstrated that some Panchakarma treatments and internal Ayurvedic medications are helpful in the management of AS. According to Ayurveda, the patient was identified as having "Asthimajjagatavata" and was given different Panchakarma treatments, including Abhyanga, NadiSwedana, yogbasti, and Kati Basti, as well as internal medications for 30 days. Indicators and symptoms like back discomfort, tenderness and tingling sensation showed encouraging results without producing any negative consequences.