Hypertension is a significant public health concern worldwide, contributing to cardiovascular diseases and mortality. This study aims to evaluate the comparative effectiveness of individualized homeopathic treatment (IHT) and therapeutic lifestyle changes (TLC) in managing essential hypertension over an extended period. A randomized, longitudinal study was conducted at the OPD department of Dr. B.R. Sur Homeopathic Medical College, Govt. of NCT of Delhi, enrolling 93 patients diagnosed with Stage 1 and Stage 2 essential hypertension. Patients were assigned to IHT or TLC intervention groups, with blood pressure levels and clinical outcomes measured over 12 months. Statistical analysis, including Mann-Whitney U tests and Wilcoxon signed-rank tests, assessed systolic and diastolic blood pressure changes. The findings highlight the role of individualized homeopathic medicines in reducing hypertension symptoms, emphasizing the potential of integrating homeopathy with lifestyle modifications for long-term management.