Aim: The purpose of this study is to use clove and cumin extract to produce the selenium nanoparticles via green approach. Selenium nanoparticles synthesized using clove and cumin formulation nanotechnology explores a lot of interesting approaches in the field of biomedicine. Researchers have recently developed interest in biomolecule-mediated nanoparticle production because of its eco-friendly and non-toxic properties. Clova and cumin have long been used in traditional medicine to treat various illnesses. Materials And Method: Collection of clove and cumin extract then 1 g of clove and cumin, powder was dissolved in distilled water and boiled for 5–10 min at 60–70C. The solutions were then filtered using Whatman No. 1 filter paper. The filtered extract was collected, synthesis of selenium nanoparticles using an herbal formulation, and to finalise the antiinflammatory activity of selenium nanoparticles.