Background: Hypertension is an important condition among adults, affecting nearly one billion people worldwide. Treatment with appropriate medication is a key factor in the control of hypertension and reduction in the associated risk of complications. However, compliance with treatment is often sub-optimal, especially in developing countries. Aim: Assess the level of compliance with therapeutic regimen among patients with hypertension. Design: Descriptive exploratory research design was used in this study. Setting: This study was conducted at the medical department in EL-Sahel Educational Hospital. Sample: A purposive sample of (120 patients) with hypertension at the age of ≥18 years with a confirmed diagnosis of hypertension for six months. Tools: tool(1) Structured Interview Questionnaire consists of two parts, part 1: Patients ' Socio-demographic characteristics, and part 2: Patients ' Medical Data. Tool(2) Patients ' Compliance Assessment Questionnaire. Results: Based on the findings of the present study. About half of the studied patients have a high level of compliance and less than one-third of them have a moderate level of compliance. Additionally, less than one-third of the studied patients have a low level of compliance. Conclusion: The current study clarifies that there was a high significant positive correlation between all domains of patients’ compliance at p-value <0.01. Recommendations: Further studies are needed to assess compliance level in a larger community-based sample and to investigate the effectiveness of interventions expected to produce better compliance with therapeutic regimen among hypertensive patients.