Background: Although scaling and root planing (SRP) are the gold standard in nonsurgical periodontal treatment, it does not ensure complete eradication of all putative periodontal pathogens. So, subgingival irrigation is performed in addition to non-surgical debridement for removing periodontal pathogens by both mechanical and chemical action. The goal of the present study was to assess and compare the clinical efficacy of two episodes of subgingival irrigation using 0.2 percent chlorhexidine and 5% moringa oleifera combined with SRP. Materials and Methods: Totally 15 patients with less than or equal to 4 mm of attachment loss as seen in Stage I and Stage II Periodontitis were recruited. From each patient, 2 periodontal pockets that are not adjacent and have a probing depth of minimum 6 mm were selected. Each patient’s two deep periodontal pockets were given irrigation treatments, one with CHX digluconate 0.2 percent (control group) and the other with Moringa oleifera 5 percent (test group) in two episodes. Pre-irrigation (day 0), days 7, and 28 post-irrigation measurements of the plaque index (PI), gingival index (GI), probing pocket depth (PD), and clinical attachment level (CAL) were recorded. Results: Following irrigation, the mean PI and GI scores decreased for both groups, with the moringa group experiencing a statistically significant greater decrease than the chlorhexidine group. The Moringa group had a greater reduction in PD and CAL than the CHX group. Conclusion: The clinical outcomes of this investigation imply that subgingival irrigation with 5 percent Moringa oleifera may be an effective adjunctive treatment for patients with chronic periodontitis