The peripheral blood markers are cheap, easy available and revelant indicators in patients with various diseases including cancer, sepsis, myocardial infarction and renal dysfunction. In recent years, there has been a growing interest of usefulness these biomarkers in heart failure (HF). Many reaearchers confirmed good prognostic value of lymphocyte to total leukocyte ratio (RLC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and red cell distribution width (RDW), in risk stratification in HF. In the course of HF, inflammation proceses and activation of sympthatetic system may explain deviatation of these biomarkers. The present study is a review of the current knowledge on the role of RDW, NLR, PLR, and RLC in assessment of prognosis in patients with HF.