Background:. Coping with systemic lupus erythematosus (SLE) can be challenging due to chronic pain, life style change and psychological problems associated with the disease. Aim: to assess coping styles among patients with systemic lupus erythematosus and find out the relation between coping styles and systemic lupus erythematosus . Design: descriptive correlational research design was used to conduct the study. Setting: the current study was conducted in the rheumatology clinic in Cairo university hospitals (Kasr Elainy).Sample: convenient sample (96) of SLE patients Tools:2 tools were used for data collection.; 1st tool – sociodemographic and medical history sheet. The 2nd tool –brief COPE scale. Results: the mean age of the studied patients was 32.19±9.20. majority of studied patients were female (91.7%). Furthermore 70.8% of the studied patients had moderate level of approach coping styles while, 59.4% of them had low level of avoidant coping strategies. Also(75%) of the studied patients had moderate levels of total coping styles and (14.6%) of them had low levels of total coping styles. while only 10.4% of them had high levels of total coping styles. Conclusion: there is a significant statistical relationship between total coping levels of the studied patients and their marital status and educational level, in addition there is a significant statistical relationship between total coping styles of the studied patients and their skin rash. Recommendations. Studying the relation between disease activity and coping styles among patients with SL.Conducting psychoeducational program for enhancing coping styles among patients with SLE.