Objectives: This study aims to assess the knowledge level, behavior, and attitude of dental practitioners regarding the absolute maximum dose of local anesthetics, their MRD, and systemic complications. Materials & Method: An electronic survey was distributed through social media platforms to dental practitioners in Jeddah. The survey consisted of 4 sections: demographic information, knowledge, behavior, and attitude. Cronbach’s alpha was used to test for the validity 0.86. Results: A total of 403 participants completed the questionnaire, with a response rate of 60%. Of all, 55.8% were females. The majority were undergraduate students 42.4%, and below the age of 25 44.9%. For the question “what is the MRD/ kg for 2% lidocaine with Epinephrine?” we found a statistically significant difference between the professional rankings p=0.001. Although the undergraduate dentists were the least group to answer the questions “What does a 2% local anesthetic solution mean?”, there was no statistically significant difference between those who answered correctly. Conclusion: We found many of our participants to have false knowledge regarding the topics of LA, MRD/kg, and LAST. We believe that the current levels are not acceptable, and that more efforts must be made to raise the knowledge pertaining to this topic.