Diabetic foot infections (DFIs) are serious long-term consequences of diabetes, and they provide a diagnostic difficulty since it is exceedingly challenging to distinguish between osteomyelitis (OM), soft tissue infection (STI), and Charcot's osteoarthropathy. However, in order to design the patient's best course of therapy, such a differential diagnosis is essential. However, it would be ideal to have a non-invasive test that is capable of detecting, localising, and assessing the degree of the infection with high accuracy. Currently, the gold standard for diagnosis is the isolation of the pathogen from bone or soft tissues. The best way to treat diabetic patients with infectious problems is through a multidisciplinary approach, although there are currently no definitive diagnostic flow charts available. This review intends to give a general overview of multimodal imaging for the diagnosis of DFI and to provide clinicians with evidence-based responses when they request that radiologists or nuclear medicine (NM) doctors examine their patients.