Sealer extrusion causes damages to the surrounding periradicular tissues and anatomical structures. Symptoms such as pain or swelling may be present causing discomfort to the patients. Sealer extrusion may also lead to failure of endodontic therapy.The purpose of this study was to evaluate the association of pain in root canal treated teeth with sealer extrusion. The study was designed to include all dental patients of the ages 20-61 years undergoing retreatment of root canal treatment (Re-RCT) for sealer extrusion. This study included 258 participants who required Re-RCT. The final data used for analysis were patients with sealer extrusion which was n=15. Age, gender and tooth involved was documented. Data was collected and tabulated in Excel. Data was analysed by descriptive statistics and chi square test using SPSS software. The total occurrence of pain in root canal treated tooth with sealer extrusion among the study population was found to be 66.6% (10/15). Higher incidence of pain was noted in lower posterior teeth 33.3% (5/15). In the present study, pain in the root canal treated tooth with sealer extrusion was recorded in 66.6% of the cases, with higher predilection in male population. Experience of pain was found to be higher in the age group 20-30 years. The pain was more often associated with lower posteriors.