Introduction: Dysmenorrhea is the most common symptom among all menstrual problems. It is expected that women will use drugs in the premenstrual and menstrual days to alleviate their symptoms. The aim of this study was to investigate the relationship between drug use and primary dysmenorrhea among students living in the dormitory of Shahid Beheshti University in Tehran, Iran. Materials and Methods: This descriptive study was conducted on 260 female students, who were living in the dormitory of Shahid Beheshti University in 2020 and consuming drugs, using the assist-who questionnaire. Dysmenorrhea pain was measured based on VAS questionnaire. The results were analyzed using SPSS software version 22. Results: Among 260 female students, 15 (5.76%) reported no pain, 46 (17.69%) reported low pain, 120 (46.51%) reported moderate pain and 79 (30.38%) reported severe pain. Also, 65% of participants reported smoking. Analyzes showed that there was no relationship between drug use and pain. Also, according to the analysis, the amount of pain decreased significantly with age. Conclusion: A large percentage of girls reported moderate to severe dysmenorrhea pain. Given the high prevalence of dysmenorrhea and the high consumption of drugs among girls to reduce these pains, it is felt that dysmenorrhea is a high priority for women's health and a well-written program should be developed to control this problem