Introduction: Nutmeg is the seed or ground species of several species of the genus Myristica . Myristica fragrans is a dark leaved evergreen tree Cultivated for two species derived from its fruit. Nutmeg oleoresin is naturally obtained by the pleasant, warm taste. It is semi solid, waxy resin with colours ranging from white to light orange. Nutmeg oleoresin is primarily used in flavouring applications and it is also used in baked products, meat, poultry, seafood and seasonings. Nutmeg is rich in anti-inflammatory compounds called monoterpenes,including Sabinene, terpineol and pinene. This may help to reduce inflammation in our body and benefit those with inflammatory conditions. Aim : The aim of the present study was to evaluate the anti - inflammatory activity of nutmeg oleoresin assisted copper sulphide nanoparticles. Materials and methods: The nutmeg oleoresin mediated copper sulphide nanoparticles were synthesized and were confirmed by UV spectroscopy. The antiinflammatory property of the prepared nutmeg oleoresin mediated copper sulphide nanoparticles was assessed using albumin denaturation inhibitory assay technique. Results: The present study showed an inhibition of 30% in 10µL and 90% in 50µL of NMO CuNPs. The nutmeg oleoresin mediated copper sulphide nanoparticles showed good anti-inflammatory activity with increasing concentration of the nanoparticle. Conclusion: In the present study the nutmeg oleoresin mediated copper sulphidenanoparticles have shown good anti- inflammatory activity. In the future this can be developed into a very successful drug for anti-inflammatory action after evaluating the anti inflammatory activity in animal models.