Background: Coronavirus infection (COVID-19) has triggered unparalleled worldwide health and economic calamity. Purpose: To investigate the effects of COVID-19 on the quality of life (QoL) in the general Saudi population and assess the influence of perceived social support. Design: Cross-sectional research was carried out on a sample of Saudi Arabian individuals. Participants: Three-hundred-forty-seven adults voluntarily participated in and completed the survey. Methods: This cross-sectional study used a nameless online survey. Outcome measures: QoL was measured using the Short-Form 36-item Survey (SF-36). The SF-36 comprises 36 measures that assess subjective mental, social, and physical health. Data analysis: Two multiple regression analyses were performed on all 35 variables and one response. Result: Most respondents are neutral about the effect of the COVID-19 infection on their overall health. Regarding their feelings, the average respondent has been nervous, energized, depressed, calm, faithful, sad, frustrated, tired and has had a physiological problem during the 4-weeks infection period. Conclusion: We detected a statistically significant correlation between the COVID-19 score and the QoL score. These results demonstrate how significantly COVID-19 has impacted the QoL domains.