Periodontal disease is the most common oral condition of the human population. Several risk factors such as smoking, poor oral hygiene, diabetes, medication, age, hereditary, and stress are related to periodontal diseases. Robust evidence shows the association of periodontal diseases with systemic diseases such as cardiovascular disease, respiratory diseases and diabetes. The aim of this study was to assess the prevalence of periodontitis among patients with and without systemic diseases. This was a retrospective cross-sectional study which was conducted using the patient records from the Department of Periodontics, Saveetha Dental College and Hospitals, Chennai. 1000 patients were chosen by non-probability sampling and were categorized into two groups; Group 1 (n=500): patients without systemic diseases and Group 2 (n=500): patients with systemic diseases. Data regarding the study participant’s periodontal status was collected and then subjected to statistical analysis. It was observed that out of 500 systemically healthy patients, 135 patients suffered from periodontitis, 365 patients suffered from gingivitis and out of the 500 systemically compromised patients, 412 patients suffered from periodontitis and 88 patients suffered from gingivitis. In the present study it was observed that 82.4% of systemically compromised patients had periodontitis and 27% of systemically healthy patients had periodontitis. From this, it was concluded that systemically compromised patients are more prone to periodontitis in comparison to systemically healthy patients.