Aim: To study synergistic effect of clove and cinnamon extract against oral pathogens- an in vitro study Materials And Method: The plant extract was prepared using 1g of cinnamon and 1g of clove added to 10 ml of distilled water. Placed in the heating mantle for about 20 minutes for condensation and was stored in a centrifuged tube. Using miller hinton agar, the organism was lawn cultured, later well cut cut and dined in micro plate. About 50µl of sample was used, and the micro plate was incubated for 24 hrs at room temperature (37°c) and the zone of inhibition was measured. Conclusion: Cinnamon and Clove extract has considerable synergistic effect against Streptococcus mutans and Enterococcus and a new tool for minimally invasive and adhesive dentistry avenues.