Coronavirus is known to be the leading cause of lung infection and mortality in 2020. In the meantime, recognizing the factors influencing the increase in the immune system and better therapeutic performance is highly debated. Decreased exposure to sunlight leads to vitamin D deficiency and thus to an inherent immune deficiency that subsequently acts as a trigger for the virus replication. Numerous observations indicate the role of various vitamin compounds in corona disease. This paper examines the role of fat-soluble vitamins in the immune system and its effect on the patients with corona among the pregnant women. Studies show that low concentrations of vitamins D and A increase the risk of the disease incidence. Vitamins also amplify the risk of corona in the people with high-risk factors such as obesity, diabetes, kidney and liver problems, by affecting liver function and changes in retinoid metabolism. Adequate levels of vitamins can be presented as a potential strategy for the prevention and treatment of corona.