Renin-angiotensin system is involved in the regulation and development of several cardiovascular diseases. AT1 and AT2 angiotensin II receptors participate in cardiovascular remodeling because the expression of these receptors and their ratios under different cardiac pathological conditions may be important in terms of myocardial function and structure. Hyperbaric oxygenation therapy (HBO) combined with antioxidant vitamins (C and E) may be beneficial in myocardial ischemia, but the mechanisms that cause these effects are not entirely clear. This study aims to examine whether the concomitant use of these therapies results in the inhibition of the expression of AT1 receptors and increases the expression of AT2 receptors. A model of acute myocardial infarction (AMI) in Wistar rats was used to determine if exposition from 1 to 3 sessions of HBO with concomitant administration of vitamins C and E has an effect in the expression of AT1 and AT2 receptors of the heart. The obtained results suggest that after administration of 3 sessions of HBO and Vitamins C and E the expression of AT1 receptors significantly reduces while the expression of AT2 receptor increases dramatically, so we can state that this combined therapy is beneficial for patients with AMI