In this report, green synthesis of silver nanoparticles was achieved by Calotropis gigantea flower extract which act as reducing and capping agent. The synthesized silver nanoparticles were characterized by UVVisible spectroscopy, SEM-EDX.UV Visible spectra shows the maximum absorbance peak at 430nm which confirms the formation of silver nanoparticles. SEM-EDX analysis reveals the spherical shape of silver nanoparticles and size of about 30-35nm. The EDX spectra reveals the presence of elemental silver as 70%. The antibacterial activity of Calotropis gigantea flower intervened silver nanoparticles against Shigella and Vibrio cholerae shows enhanced activity. The silver nanoparticles also shows potential antioxidant activity as the concentration increases and the absorbance is noted at 517nm